Stroke is more often disabling than fatal, Stroke survivors have a high risk of recurrence; hence, the interest in looking at the therapeutic aspects, which are essentially based on multidisciplinary management allowing motor and cognitive rehabilitation. However, the search for, but also the stimulation of a neurochemical deficient factor represents an essential approach for a better recovery. Therefore, our investigation has focused on a sample of 20 hemiplegic patients with multiple cognitive deficits admitted to the ANNABA Specialized Hospital, which has allowed us to obtain interesting data on the existence of deficits in serotonergic, dopaminergic, gabaergic and cholinergic neurotransmission through a non-invasive test established by Dr. Braverman was used as a support to which the pre-selected patients agreed to respond. From these results, a moderate serotonin deficiency was found. This deficiency is mainly present in women and has an impact on the patients’ mental state as well as on the cognitive and on the motor recovery.