The synthesis of pesticides has advanced significantly over the past century. Synthetic pesticides, on the other hand, have swiftly proven to be aggressive toward non-target creatures, such as helpful insects, animals, and people, in addition to their persistence in nature, which upsets ecological balances. This paper describes the toxic effects of Ruta chalepensis (Rutaceae) ethanolic extract on Drosophila melanogaster courtship and course of sexual behavior, mortality of Drosophila melanogaster larvae (determination of lethal concentrations and lethal times), and choice of oviposition environment and reproduction in this fly's adults. The plant's aqueous extract inhibits both mating and reproduction.