The entire world has fallen to a psychological panic as a result of the coronavirus disease 2019 (COVID-19) pandemic, and the pandemic has triggered extreme psychological stress, such as fear, anxiety, and depression in people worldwide. More than 80% of all diseases is related to stress, and extreme stress contributes to the onset of various diseases. This study used a one-group pretest-posttest design to investigate the effects of shortened self-foot reflexology on stress and depression in older women. Perceived stress and depression decreased in the experimental group, showing a significant change after shortened self-foot reflexology. This pilot study confirmed the feasibility of a shortened self-foot reflexology and shed light on the possibility of developing a shortened self-foot reflexology to be applied in communities to reduce perceived stress and depression in older women during the current pandemic situation.