Journal ID : ALS-18-09-2020-5512
[Volume - 10, Issue - 04]
Total View : 642
Title : Correlation of Apolipoprotein B with lipid profile and Non- HDL cholesterol as markers of atherosclerotic risk in type 2 Diabetic patients with Hypertension
Abstract :

Diabetes mellitus and Hypetension are the gateways to cardiovascular diseases and they never hesitate to conquer any community or population. Patients are at high risk of cardiovascular disease when Diabetes Mellitus and Hypertension coexist, which requires accurate risk assessment and focused treatment. Measurement of Apolipoprotein- B and Non -HDL cholesterol as part of a routine lipid profile could play a pivotal role in optimal atherosclerotic risk reduction. Hence, we studied the relationship between Apolipoprotein-B, Non -HDL cholesterol and lipid profiles in diabetic patients with Hypertension. Apolipoprotein-B, Lipid Profile and Non-HDL cholesterol were estimated in Type 2 Diabetic patients with hypertension and they were compared with age and sex-matched healthy controls. Serum was analyzed for lipid profile in a fully automated Beckman AU 480 analyzer, Non-HDL cholesterol was calculated value and Serum Apo-B by the turbidimetry method was done in a semi autoanalyzer. Significant increase in values of Apolipoprotein-B, fasting blood sugar, total cholesterol, LDL- cholesterol, Triglycerides, and Non-HDL cholesterol was seen in type 2 diabetic patients with Hypertension compared to controls. There was a significant positive correlation between Apolipoprotein-B and fasting blood sugar, total cholesterol, LDL-cholesterol, triglycerides, and Non-HDL cholesterol. The findings of the present study stated that the majority of the patients studied had low HDL-C, elevated non-HDL-C, elevated total cholesterol, high triglycerides, elevated LDL-C, and elevated Apolipoprotein-B. Apolipoprotein-B had a positive linear correlation with total cholesterol, triglycerides, LDL-C, non-HDL-C. The strongest positive correlation was with non-HDL-C. Patients with low HDL-C had high Apo B levels

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