Journal ID : ALS-25-08-2020-5496
[Volume - 10, Issue - 03]
Total View : 413
Title : BISPHENOL A AND EPIGENETIC RISK IN FETAL HEALTH AND EMBRYONIC DEVELOPMENT
Abstract :

Bisphenol A (BPA) is a chemical compound consisting of diphenylmethane base with two hydroxyphenyl functional groups. It was first synthesized in 1891 and is currently used globally in the production of consumer products such as plastic bottles, food and beverage cans, dental sealants, eyeglass lenses, medical devices and as an additive in other plastics. BPA has been extensively studied and has become widely known as endocrine disrupting chemicals (EDCs). Several studies reported that BPA is not only disruptive to endocrine system, but also a potent developmental toxin at very low doses. Exposure to BPA in early life may cause infertility, early puberty, cancer, and disrupt normal behavior. Pregnant women, infants and young children are the most vulnerable groups to the harmful effects of BPA. Recent discoveries linked BPA exposures to risk of metabolic diseases, diabetes, cardiovascular diseases, neurodevelopmental problem and attention deficit and hyperactivity disorder (ADHD) due to their epigenetic inheritance effects that were transferred from the parents intergenerationally. However, to date, studies relating to BPA’s effects on fetal health and development especially on its potential to modify and disrupt epigenome profiling in early embryogenesis remain scarce and are still inconclusive. Hence, this review is written with the intention of providing an additional overview of the effects of BPA in fetal health and development

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