Asia Life Sciences

Abstract : The utilization of both plant extracts and phytochemicals, with remarkable antimicrobial properties, can be of great importance for therapeutic applications, particularly in the treatment of diseases caused by Multidrug resistant microorganisms. The frame work of the current study was mainly designed to study the efficacy of some naturally existing plant derived, fungal derived and algal derived antimicrobial substances against the multidrug resistant microorganisms isolated from diabetic foot lesions of the patients. The pus samples collected from diabetic foot lesion patients in a Tertiary care hospital were processed immediately in the Microbiology laboratory for the isolation and identification of pathogens through morphological, cultural and biochemical characterization. Antibiotic susceptibility pattern of isolated pathogens was checked by Kirby Bauer disc diffusion method using Clinical and Laboratory Standards Institute (CLSI) guidelines. Different naturally available compounds like Honey, spices, spirulina and mushroom were used to determine their antibacterial activity against the wound isolates through agar-well diffusion method at varying test concentrations against Staphylococcus aureus, Klebsiella pneumoniae, E. coli, Pseudomonas aeruginosa, Proteus mirabilis, Coagulase negative staphylococci, Enterococcus faecalis, E. coli 25922 and S.aureus 25927. The results obtained in the current study propose that bioactive and structurally diverse fungal metabolite i.e. mushroom extracts, herbal products like spices showed mild antibacterial activity while to honey and spirulina at highest concentrations. The study helps in the development of valuable pharmaceutical products and may be one of the better options for treating the infections caused by multidrug resistant bacterial isolates

Abstract :

Ultraviolet (UV) light has been an important source in human health throughout human evolution. However, modern lifestyles, indoor jobs, cultural myths, religious beliefs and the increase of globalization has drastically reduced UV light exposure in humans, amounting to growing cancer rates, diseases and worldwide health deterioration. This commentary details various human activities, lifestyles and their effects on health worldwide. It also examines misinterpreted findings pertaining to the lack of UV light exposure that could further undermine existing health issues. UV light producing technologies to reduce adverse effects on human health are currently being used and are very effective. They are safer than sunlight, available at any time, inexpensive and could reduce healthcare costs by decreasing drug use and extensive cancer therapies. Public health agencies and healthcare providers throughout the world should make individuals aware of UV light exposure benefits.

Abstract :

Excessive salt consumption is one of the hypertension and kidney disease factors, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor which leads to the decrease of blood pressure, but also activates peroxisome proliferator activated receptor gamma (PPAR-γ) and inhibits transforming growth expression factor of beta-1 (TGFβ-1). Whether telmisartan decreases the kidney collagen volume fraction of excessive NaCl-induced Wistar rats are studied in this experiment. Twenty-five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg BW. The treatments were given every day within 8 weeks. At the day of 56 all rats were sacrificed by mean of neck dislocation and operated to take the kidney. The collagen was stained by picrosirius red staining. Data were expressed as mean ± standard deviation. They were analyzed by parametric test (analysis of variance-ANOVA and paired samples t-test) or nonparametric test (Kruskal-Wallis). A value of p<0.05 was considered statistically significant. The results showed that intraglomerular and extraglomerular collagen volume fraction were lower in telmisartan-treated Wistar rats group than negative control group (0.05<p<0.05). In conclusion, intraglomerular and extraglomerular collagen volume fraction were lower in 8% sodium chloride-induced and telmisartan-treated male Wistar rats than the items of negative control group

Abstract :

Tropical endomyocardial fibrosis is a peculiar disease involving the heart. Recent reports on it have appeared in alphabetical order in Brazil, Casablanca, France, India, Mozambique and the United Kingdom. Therefore, this case report from Nigeria is deemed to be worthy of documentation.

Abstract :

Production of nanostructured materials, similar to the complex structure of nano-calcite of hard tissues, eggshell, teeth and bone, are an attractive field of research. Calcium phosphates with clinical applications, such as hydroxyapatite (HA) (Ca10 (PO4)6(OH)2) have been widely used in regeneration of bone and fabrication of medical implants, mainly due to the chemical composition and structure similarity between HA and the mineral part of bones and teeth and also as gene and drug delivery is used. High surface area of HA make it useful for drug release. Moreover, it has antibacterial property and potential applications in rapid microbial detection, treatment of heavy metals from aqueous solutions. Biological synthesis has been attracted more attention for compatibility to human safety